Cinobufagin
Description References- Product Name
- Cinobufagin
- CAS No.
- 470-37-1
- Chemical Name
- Cinobufagin
- Synonyms
- FEMA 2288;AKOS 233-01;CINOBUFAGIN;16-beta)-bet;cinobufagine;AKOS B004228;CINOBUFAGIN(P);Cinobufagin std.;Cinobufagin (6CI);Chinese bufotoxin
- CBNumber
- CB2206701
- Molecular Formula
- C26H34O6
- Formula Weight
- 442.55
- MOL File
- 470-37-1.mol
Cinobufagin Property
- Melting point:
- 133 °C(lit.)
- Boiling point:
- 300 °C(lit.)
- Density
- 1.261 g/cm3
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- pka
- 15.10±0.70(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
Safety
- Hazard Codes
- Xi,T+,Xn
- Risk Statements
- 36/37/38-26/27/28-42/43-20/22
- Safety Statements
- 26-36-45-36/37/39-22-24/25
- RIDADR
- UN 2811 6.1/PG 1
- WGK Germany
- 3
- RTECS
- GD7850000
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P350IF ON SKIN: Gently wash with plenty of soap and water.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C3460
- Product name
- Cinobufagine
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $304
- Updated
- 2024/03/01
- Product number
- C3460
- Product name
- Cinobufagine
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $908
- Updated
- 2024/03/01
- Product number
- 19844
- Product name
- Cinobufagin
- Packaging
- 5mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 19844
- Product name
- Cinobufagin
- Packaging
- 50mg
- Price
- $566
- Updated
- 2024/03/01
- Product number
- 19844
- Product name
- Cinobufagin
- Packaging
- 10mg
- Price
- $206
- Updated
- 2024/03/01
Cinobufagin Chemical Properties,Usage,Production
Description
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
References
1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html
Description
Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.
Uses
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Definition
ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
Cinobufagin Preparation Products And Raw materials
Raw materials
Preparation Products
Cinobufagin Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2784
- Advantage
- 58
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8449
- Advantage
- 60
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4662
- Advantage
- 60
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19553
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9926
- Advantage
- 65
View Lastest Price from Cinobufagin manufacturers
- Product
- Cinobufagin 470-37-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-10-10
- Product
- Cinobufagin 470-37-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-10
- Product
- Cinobufagin 470-37-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26